Barcelona is ahead on the head-to-head tiebreaker, but Madrid still has a game in hand. He now has 23 goals in games between the two clubs, five more than Madrid great Alfredo Di Stefano and eight more than Cristiano Ronaldo.
The pace didn't drop off, and Real Madrid midfielder Luka Modric forced a fine save from Barcelona custodian Ter Stegen.
Messi's second goal at the Santiago Bernabeu Stadium on Sunday was a last-minute victor that gave him 500 career goals with Barcelona, and he was honored for the milestone before the Osasuna game, with a huge banner displayed on the stands with the words "Thank you Leo". "He is a very special player".
It looked as if the game would end in a 2-2 draw which would have maintained Madrid's lead, but Messi got on the end of a surging counter-attack to sweep the ball home and to throw the title race wide open once again.
"He saw Ronaldo scoring his 100th goal in the Champions League before him".
Rainout pushes back big league debut for Phils' Pivetta
Though Rollins was 36, he was a Phillies legend, if not statue-eligible, then at least a candidate for a retired No. 11. He is expected, however, to join them in Los Angeles over the weekend and likely will start against the Dodgers Sunday.
"Messi had a good game". The last time he had scored against Madrid was with a hat trick at the Bernabeu in a 4-3 win in the league in 2014.
Barca took the lead through Ivan Rakitic who scored with a wonderful left foot shot from 20 yards out which left Navas helpless with just 17 minutes left on the clock.
Madrid stormed out of the blocks at the Santiago Bernabeu, Casemiro the unlikely scorer of the game's opening goal in the 28th minute.
Messi's celebration, parading his shirt, sparked a fierce reaction from many Madrid fans on the stands behind the goal, where only a few people wearing Barcelona colors could be seen. Andre Gomes and Paco Alcacer also scored twice for Barcelona, and Javier Mascherano netted his first goal with the Catalan club to complete the rout. "I hope he will only retire several years from now".