Washington trailed 6-2 in the seventh before coming back.
Jayson Werth led off the ninth with a homer, and Bryce Harper doubled.
Last year, the teams played from August 22-25, also playing the first two in Baltimore and the final two in Washington.
Ruiz earned another standing ovation a day after he returned and was honored with a video tribute that highlighted his career with the Phillies. Since then he has posted a 2-0 record with a 0.69 ERA.
Hunter Pence hit a tying single off closer Jeurys Familia in a four-run ninth that gave the Giants (12-23) only their third victory in 11 games.
Godley (1-0) allowed one run and struck out six. He missed all of 2013 because of injury and didn't make the majors until 2016, when he went 10-6 with a 4.02 ERA in 36 games (14 starts). He'll bat second in the order and play left field.
Jeremy Jeffress (1-2) allowed singles to the Nos. The over/under total for the contest is listed at 8.5 runs.
The Milwaukee Brewers got past the Boston Red Sox 11-7, the Minnesota Twins beat the Chicago White Sox 7-2 and the Houston Astros claimed an 8-3 win against the Atlanta Braves.
"That lineup over there, if you lose your focus for a second, they can put a run or two up on you", Wieters said.
The Cardinals' 6-0 swing was the first undefeated trip of at least six games in their 126-year history.
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Miley was unable to get through the first inning in his last turn after he was hit with a pair of line drives before he was removed for precautionary reasons.
Marquez had a no-hit bid going until Kris Bryant's double leading off the seventh inning.
"It's tough facing a guy you threw so many innings to".
Ian Desmond hit a go-ahead sacrifice fly in the fourth that was set up by shortstop Javier Baez's error. Brad Brach blew the save, giving up all three runs in the ninth while recording just one out.
Scherzer issued two walks over the first five innings and held the Orioles hitless until Seth Smith homered with one out in the sixth. It was the first homer of the year for Taylor, who had two hits.
But, since 2012 when the Orioles and Nationals both made the playoffs for the first time, Baltimore has won five consecutive season series.
Roberto Osuna (2-0) pitched a ideal ninth.
Adam Jones began the improbable comeback with a home run and Trumbo completed the turnaround with a 12th-inning RBI single that provided Baltimore with a 5-4 victory on Tuesday night.
Logan Morrison, Rickie Weeks Jr. and Colby Rasmus homered for the Rays; Rasmus had a grand slam off Peter Moylan in the eighth. The home team has now won six of the last seven in this series.