To become Australia's first French Open champion since Rod Laver in 1969, he will need to win more matches in a fortnight than he's played all year on clay. Dolgopolov is 2-1 in head-to-head matches with Wawrinka.
Top-seeded Andy Murray is safely through to the second round of the French Open after beating Andrey Kuznetsov of Russian Federation 6-4, 4-6, 6-2, 6-0.
The Scot needed two hours and 32 minutes to finish off the victory and is still seeking to recapture last season's stellar form.
'I don't really know if there is a changing of the guard, ' he said.
Three times champion Mats Wilander told Reuters that agreeing to stop had been a "rookie mistake" for the German. But it was quite windy today.
Madison Keys ended a four-match losing streak by winning on clay for the first time this year, beating Ashleigh Barty 6-3, 6-2 at the French Open.
"I think that the tournament is getting better every day".
Australian Nick Kyrgios shrugged off injury concerns and kept his emotions in check to outclass Germany's Philipp Kohlschreiber 6-3, 7-6, 6-3 on Tuesday and book his spot in the second round of the French Open.
The 19th-ranked Kyrgios disputed the chair umpire's ruling when a call went against him as he had a break point for 5-4.
"I'm always going to be confident".
Konta upbeat despite shock French exit
The 31-year-old beat the Brit 1-6, 7-6 (2), 6-4 in a match lasting two hours and 18 minutes. Svitolina will next face Tsvetana Pironkova after she beat Mona Barthel 6-0 6-4.
"I took Rome off but I had tournaments to get ready for so it's not really the right rest that it needs.
That's the way it goes", said Zverev, who broke a racket over his leg during his 6-4, 3-6, 6-4, 6-2 loss to Fernando Verdasco.
Lokoli was angered by what he interpreted as gamesmanship, saying Klizan appeared to be dogging it in moments - such as the 6-0 fourth set - hampered by his leg: "I'm wondering if he's going to retire or no, because now he's not running anymore, you know?"
"They're okay. They're not great, but they're not awful to keep me out so we'll see how it goes", he said.
Thanasi Kokkinakis faces eighth-seed Kei Nishikori in a daunting return to grand slam tennis after 18 months battling injury.
Also advancing were 13th-seeded Tomas Berdych of the Czech Republic, 15th-seeded Gael Monfils of France, 21st-seeded American John Isner and South Korea's Hyeon Chung.
The 18th seed overpowered Kohlschreiber with 20 aces and a series of scorching forehand winners to set up a comfortable 6-3 7-6 (7-4) 6-3 win.
The match was suspended on Monday because of darkness after the players split the first two sets. He can play spectacularly well and spectacularly poorly-often within in the same match set game point.
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