The Spain global told Marca this month that doctors told him at one point he may never walk again and that his foot may even need to be amputated, but he is targeting a return in January, having been left out of Arsenal's Premier League squad for the first half of the season.
The Spaniard has been sidelined since October 2016 with an injury that was supposed to have kept him for just a short period.
The 32-year-old then contracted gangrene after the operation and revealed to Spanish newspaper Marca he could have had his foot amputated.
Cazorla required a skin graft from his arm, lost eight centimetres of tendon from his right foot and came close to amputation.
Santi Cazorla's genius has reached mythical proportions for Arsenal fans, and it seems now that we have never found a playmaker to emulate his silky skills for the Gunners.
'It started with a pain on the achilles and it has gone from worse to worse.
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"It is the worst injury (I have seen)", the Gunners boss said.
I wish (he returns in January). I hope he comes back in January.
'I saw him a month ago and told him to practise as best he can.
When it was put to Wenger if there were doubts over whether Cazorla would ever play again, the Frenchman replied: "Let's not talk about that, but I hope you are wrong".
Speaking during his pre-match press conference ahead of Arsenal's premier league clash with Tottenham, Wenger said; "What we want from him is to add goals to his game, and these kind of experiences (playing and scoring for Nigeria) will help him to be confident to score".