Lady Gaga, who performed via telecast from a tour stop in Washington D.C., told her fans that "If you feel different, or feel not understood, don't you dare give up on who you are". Mars, who is missing the show because he's on tour in South America, will also compete for favorite male artist in both genres. Ross' mother, iconic entertainer Diana Ross, will be honored later in the show with the Lifetime Achievement Award.
The 73-year-old was cheerful and energetic as she ran through well-known songs onstage like a veteran, singing I'm Coming Out and Ain't No Mountain High Enough, among other hits, with her signature big hair.
Kelly Rowland sang along and danced while Demi Lovato performed "Sorry Not Sorry".
Two months ago, the singer took to Instagram to let her fans know why she had been laying low over the American summer.
The fan-voted American Music Awards show, televised on ABC, features performances from pop music's biggest names.
Watch the new trailer for a Wrinkle of Time
Meg with her friend and little brother discover the "fifth dimension", that is "outside the rules of time and space". A made-for-TV-movie based on the novel was produced in 2003, but it didn't quite live up to fan expectations.
Wolves was Gomez' first live performance of 2017, marking her official return to the stage after she underwent a kidney transplant as part of her lupus treatment earlier this year. Red marks, coming off like bruises and blood, appeared on her knees, hands and forehead.
Christina Aguilera was shaky when she sang a medley of Whitney Houston's songs to honour the 25th anniversary of Houston's film, The Bodyguard. The Man. But while the performers are evenly split between men and women, the nominees?
Like Mars, Keith Urban also won multiple awards, including favourite country album, country male artist and country song. "This is my family and I am sending love out to all of you our global family and I really, really love to be here", Ross said.
Bruno Mars won Artist of the Year, former One Direction member Niall Horan won New Artist of the Year and Puerto Rican singer Luis Fonsi, Justin Bieber and Daddy Yankee won Collaboration of the Year for the catchy "Despacito". Truly, K-Pop couldn't have had a better introduction to the AMAs than that.
Pink, left, and Kelly Clarkson perform "Everybody Hurts" at the American Music Awards at the Microsoft Theater on Sunday, Nov. 19, 2017, in Los Angeles.