Migraine drug makes people have fewer 'migraine days'

Migraine therapy that cuts off attacks 'big deal'

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Over the six-month trial, patients receiving Erenumab, who had an average of eight migraines per month at the start of the trial, reported having an average of five migraines per month following the treatment.

The new drugs were not tested against existing ones, only placebo treatments. Still, headache experts are enthused about the new research. He's director of neurology and director of the Headache Center at Cincinnati Children's Hospital Medical Center.

Migraine headaches affect thousands of Americans and millions worldwide. Symptoms include severe headache, dizziness, nausea, and aversion to light.

Lipton noted that there has been a "staggering record of success" in regards to the monoclonal antibody class of medicines. They attach to other proteins to disrupt how those proteins act.

It's not exactly clear how the drugs help disrupt migraines, but CGRP is known to be involved with the way nerves control pain and with blood vessel activity. Also, it was found to be abundantly present during migraine attacks.

The 16-week HALO CM trial, a collaborative study spanning 132 sites across nine countries, enrolled 1,130 patients and randomly assigned them to one of three groups. Another group received 140 mg of the drug by injection monthly. Only 18 percent of those who received placebo showed a similar reduction in symptoms. In a trial of almost 1,000 people, the drug was found to typically reduce the number of "migraine days" a person had by three or four days a month.

A new drug called Erenumab offers chronic migraine sufferers a new hope after clinical trials revealed it can cut the length of migraine attacks in half.

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Placebo effects are common in studies related to pain, including migraines. The second group received monthly fremanezumab with a starting dose of 675 mg and then 225 mg for the second and third month.

Compared with placebo, people taking erenumab 70mg were 2.13 times as likely to have their migraine days fall by half (odds ratio (OR) 2.13, 95% confidence interval (CI) 1.52 to 2.98) and those taking erenumab 140mg were 2.81 times as likely (OR 2.81, 95% CI 2.01 to 3.94).

The study also finds long-term analysis of the safety of the drug is needed. "These medications look promising".

Increased levels of CGRP have been reported in migraine and temporomandibular joint disorder patients as well as a variety of other diseases such as cardiac failure, hypertension, and sepsis. They tried the drugs in 955 individuals who suffered from migraines.

"From the adult studies, these drugs appear to be very safe", Hershey said. STRIVE, as with the monoclonal antibody developments generally, represents an incredibly important step forward for migraine understanding and migraine treatment'.

The studies are both published this week in the New England Journal of Medicine.

Any new drugs will have to be licensed by the European Medicines Agency and assessed by the National Institute for Health and Care Excellence (NICE) before they can be made available on the NHS.

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