Chelsea will need a win to assure themselves of top spot in the group.
The Reds only needed a point to qualify and finish top of the group but a team featuring six changes beat CSKA Moscow 2-1 at Old Trafford to advance in the tournament with five wins from six games.
Seeded group winners will be away in the round of 16 first legs on 13/14 and 20/21 February and at home in the return matches on 6/7 and 13/14 March. Chelsea have scored in their last 25 home games in the competition whilst the Spanish side have yet to score in their two away games so far in the competition - despite having 32 attempts at goal in those games.
Chelsea and Manchester United progressed to the knockout stages, in second and first place respectively, while Celtic claimed third to guarantee European football in the New Year in the form of the Europa League. Liverpool need at least a point to be assured of qualifying and winning the group.
One child killed, 22 hospitalized after Georgia school bus accident
The Georgia State Patrol was investigating and said "charges are pending" in the crash, which involved no other vehicles. The agency said in a news release the bus driver had lost control, veered into a ditch and slammed into a tree.
DISAPPOINTSGermany's representation in the last 16 could come down to just one team, Bayern Munich, after disappointing campaigns from the Bundesliga's best - Borussia Dortmund in particular.
Dortmund, which reached the final in 2013, is already out after failing to win any of its group games and is now competing with APOEL for the consolation of Europa League qualification from Group H. Ahead of its visit to Real Madrid on Wednesday, Dortmund has just two points from five games, the same as Cypriot team APOEL. Coming off a devastating loss at home to Juventus in Serie A, the Partenopei must win at Feyenoord on Wednesday and hope Manchester City beats Shakhtar Donetsk in Group F.
Chelsea has already qualified for the next round and will confirm top spot with a victory over Athletico Madrid, or if Roma fails to beat bottom of the table Qarabag.
On a night when Sporting Lisbon might have deprived them of second spot in Group D, last season's finalists ensured there would be no slip-ups with a 2-0 win over Olympiakos in Greece and fourth successive clean sheet. Juve won at Olympiakos 2-0 and joined group victor Barcelona, which beat Sporting Lisbon 2-0. "On Tuesday we'll need all of your support". Russian champions Spartak have to win to have any chance of progressing.