Though Spence (22-0, 19 KOs), the IBF welterweight champ, and Thurman (28-0, 22 KOs, 1 NC), the WBA/WBC champ, have attractive alternatives, including a fight against each other, they could make big money for facing Khan, especially in England.
The former unified world champion was most recently in the public eye when he appeared on ITV programme "I'm a Celebrity Get Me Out of Here" in the latter half of 2017. I'm going to get the feel of boxing again and go to training camp in a few weeks.
Having previously claimed "I just don't like Eddie Hearn", Khan has put his issues with the promoter to bed and agreed terms on a contract.
However, a shot at Spence could be easier to arrange and the American says he would have no objections to the bout, as he says Khan is a bigger name than the man he beat to become world champion. That's where I believe I belong so I need to work hard.
In November previous year, Khan said he still wants a fight with Kell Brook, but admitted they both need to rebuild their careers with wins before settling their long-running rivalry.
"It's something I would consider", he told Sky Sports.
Hearn accused the fighter of being "scared" of fighting Brook, while in August Khan said: 'The only way I would take that Brook fight is if he left Eddie Hearn.
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The meeting took place days after the visit to Pakistan by the kin of Indian national Kulbhushan Jadhav . This understanding was reiterated during the Modi-Sharif meeting in Lahore on December 25, 2015.
Khan had been at loggerheads with Hearn for years. Eddie will probably be my last promoter now'.
Brook is moving up to light-middleweight for his next fight, after years of straining to scale down to welter, but Hearn says: 'Kell would go back to 147lbs if it would bring him the Khan fight'.
A fight between the pair has always been touted, however, never came to fruition as the two boxers camps could not agree terms.
"His name is bigger because he has fought more big names [than Brook]".
With the two British brawlers now under the same stable it's now believed that the much-anticipated fight may finally happen this year. If he really wanted the fight between me and Kell Brook, he should not be speaking to me, he should be speaking to [my adviser] Al Haymon.
"I would just love to test myself against him".
Khan will shortly head back to San Francisco to begin preparations for April 21 at Liverpool's Echo Arena with his American trainer Virgil Hunter.