Sunday's encounter with City at Anfield will be fourth-placed Liverpool's first match since the departure of Brazil playmaker Philippe Coutinho to Barcelona.
Given it'll be City's last true test against a top-six team (the club's final four matches are vs. Swansea, at West Ham, vs. Huddersfield, at Southampton), if Pep's charges make it this far unbeaten, it will have the feel of a final at Wembley Stadium.
Liverpool forward Roberto Firmino, his compatriot, on Wednesday posted a message on Instagram saying "Liverpool is no longer the same without" the "magical" Coutinho.
That trio is more than capable of ensuring its team's offensive threat remains among the most unsafe in the English top flight.
"Defensively they have never had anyone - [Ragnar] Klaven, [Joel] Matip, [Dejan] Lovren - none of them are that standout centre-back that you look at and who is going to lead from the back, going to be a good talker".
Liverpool holds a super slight edge at 6-5-7 in its last 19 matches against Manchester City.
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Salah tormented the Argentine worldwide during the opening exchanges and spurned two opportunities to give Liverpool the lead before Aguero's opener. Maybe it changed City's season.
Looking ahead to Sunday's game, where do you see the key battles taking place?
Indeed, when asked to compare the two sides in December, Arsenal coach Arsène Wenger said: "We had no petrol but ideas; they have petrol and ideas".
Kane, 24, struck eight goals - including two hat-tricks - during December. Liverpool are also unbeaten at home this season and in the last 22 games against Manchester City in Anfield, the visitors have won just twice.
There isn't a team in Europe that is easier on the eye; it's not inconceivable that they'll triumph in all four tournaments they've entered. It's why there are so few league and cup doubles, and rarely any trebles, in club football - especially in England. "It's a big game for us and we are going to plan as much as possible", Guardiola said in his press conference on Friday.
"But Liverpool is such an important game, to realise again if we are able to do big things in this season, in important stages, in the Champions League".