The singer/dancer/actress will appear in guest capacity, playing both herself and her "Shades of Blue" character, New York Police Department detective Harlee Santos.
Jennifer Lopez will be reappearing on Will & Grace during the show's reboot.
It also gave Lopez the opportunity to send herself up in hilarious fashion, with her character demanding everybody wear her latest "Glow" perfume.
And Mullally reposted Lopez's selfie on her personal account, remarking on Jenny from the Block's flawlessness. She also appeared in the season 7 premiere, in which she fired her full-time back-up dancer Jack.
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NBC are yet to have revealed further details about what Jennifer will get up to in her forthcoming "Will & Grace" cameo. Back on @nbcwillandgrace This time I brought Harlee!
Karen and Lyle's marriage lasted all but 20 minutes, but Lopez was still able to make it memorable with her performance and her smooth ability to poke fun of herself. There's no nuptials on the horizon this time, but we're sure she and Jack will mix it up again. The world-famous actress-singer-dancer and Will (Eric McCormack) and Grace's (Debra Messing) neighbor then became fast friends.
Originally debuting in 1998, Will & Grace has been nominated for 83 Emmy Awards, winning 16 of them, including Outstanding Comedy Series.
Will & Grace airs Thursdays at 9 p.m. on NBC, while Shades of Blue returns for its third season.