"These are shocking and shameful comments from the President of the United States", said Rupert Colville, a spokesman for the UN High Commissioner for Human Rights.
Mr Trump's comments are extremely offensive to South Africa, said Jessie Duarte, a senior official with the ruling African National Congress.
The statement also questioned why Trump "must use this descriptor and derogatory word, when talking about countries with whom the U.S. has had cordial and mutually beneficial bilateral relations for so many years".
René Civil: "Donald Trump is more than just a cancer on the world, and not just throughout the world, but particularly for the American people".
"This was not the language used", he said in a tweet. I have a wonderful relationship with Haitians.
US Senator- "Trump is Lying" about Denying "S…hole" Country Remark
But, he added, "I also understand the president is not a career politician, and may say things that aren't politically incorrect". The New York Daily News has taken aim at Donald Trump for reportedly describing African countries as "shithole countries".
"What was really tough was the outlandish proposal made", Trump tweeted.
On Thursday, Trump sparked widespread criticism after he reportedly questioned why the USA should restore protections for immigrants from Haiti and parts of Africa. Trump said, according to people familiar with the meeting. "Probably should record future meetings - unfortunately, no trust!" he said.
On Friday, Trump denied he made the comment and also denied demanding that Haitians be removed from negotiations about protected status for people from certain countries.
There has been a push for a bipartisan effort to solve the dispute of DACA, but these latest comments from Trump have stoked divisions.
Some Republican lawmakers also were quick to condemn the president's words. "Because, if it wasn't, it means we voted for a racist - like a real one - and we'd have to get pitchforks and chase him out of the White House". Obama has frequently spoken about the importance of respecting the "peaceful transition of power", which helps explain the shift in his direct attacks on Trump during the 2016 presidential campaign versus his more veiled critiques post-Election Day.