The South African, the Nedbank Golf challenge victor past year, recorded six birdies after the turn following a front nine which saw Grace mix two birdies with one bogey.
Of the three former Major winners who survived the even-par cut Friday, Charl Schwartzel of South Africa is best placed on 208 after a 69.
"I was a little bit rusty with some of the wedge shots and things like that, but all in all very pleased with the outcome", said Grace.
He has eight European Tour career victories but has yet to lift his countryâs Open championship, which is the second oldest in the world having first been formally played in 1903.
And Jamie Donaldson recorded the first hole-in-one of this year's tournament when he aced the par-three 14th with a nine iron. And then I finally did get one on 11 and I just let the adrenaline run and it led to more birdies.
Chasing Paisley and Grace on Sunday will be a three-man group at 12-under-par, three off the pace.
Europe trail at EurAsia Cup
It gives Denmark's Bjorn a great chance to test players in a team environment before the showdown against United States of America in Paris.
Branden Grace achieved a career first of three eagles in one round as he opened with a 65 to share the lead on day one of the BMW South African Open, proudly hosted by the metro, at Glendower Golf Club, on Thursday. "It's been a fun journey, and with my son turning one on Wednesday, I'm just enjoying life and golf is no longer number one", Blaauw said.
South African Jacques Blaauw (66), American Chase Koepka (68) and Frenchman Adrien Saddier (73) are a further two shots back.
Paisley, the clubhouse leader for much of an opening round played in warm, partly cloudy conditions, birdied seven holes and bogeyed one.
"I'm looking forward to tomorrow big time".
Five-time European Tour victor Darren Fichardt of South Africa is alone in sixth on 205 after a 64, the lowest score of the day, and bettered only by Saddier this week. Sitting in your hotel room, you just think "Man, this is hard work", but you grow as a golfer because you have to deal with a lot of bad moments, which you have to take on the chin and move on.