Nacho Monreal, in particular, has been outstanding, with the Spaniard providing one goal and two assists in a performance that shows above all else that life will go on without the Chilean global.
While the Gunners could get a spark from Wenger's return, a hungry Crystal Palace side could use the relative chaos to strike, hoping to take points off Arsenal while they're reeling. Sanchez isn't coming back either, but perhaps that doesn't matter after all.
The former-Schalke defender's lack of game time suggested that he has been dropped by Wenger for the foreseeable future despite being a regular left-back for the majority of the first half of the season.
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Given Palace's recent fine form and Arsenal's poor start to 2018, it was predicted by some that the visitors could cause a shock at the Emirates. Clearly he was holding them back.
Wilshere's quick feet and passing ability have been sorely missed during his lengthy injury layoffs and last season's loan spell at Bournemouth.
For it was he who grabbed a sixth minute opener following a corner after what can only be described as Arsenal-esque defending as the Spaniard had the freedom of the six-yard box to put his team 1-0 up.
Something about Arsenal seems to bring out the worst in this Crystal Palace side.
Lacazette's last goal for Arsenal had come in defeat to Manchester United on December 2.