Aguero scored his second five minutes later from, you guessed it, a De Bruyne pass.
His second goal was a reward for his own hard work, closing down Kasper Schmeichel and forcing the keeper into a mistake before Kevin De Bruyne threaded a ideal pass in behind for Aguero to latch onto.
Leaders Manchester City host Leicester, who will again be without Mahrez after he failed to force through a move to the Premier League leaders, while Manchester United travel to Newcastle and Southampton welcome back Virgil van Dijk in a Liverpool shirt.
The footballer of the year battle continues to hot up as Aguero runs riot. The Argentine's abilities have never been recognised with individual awards which is quite astonishing given his incredible consistency in the top-flight over the years. Couldn't hear the #LCFC fans above the applause from the Man City fans around us. De Bruyne brought an even better save out of him after cutting in from the left.
DF Danilo, 6 - The defender was solid, if not spectacular when replacing Zinchenko on 65 minutes to cover the threat of Mahrez on Leicester's right.
Eminent Pakistani lawyer, activist Asma Jahangir dead
In 2013, a USA intelligence report claimed that some military officials had planned to kill her during her 2012 India visit. She was an outspoken critic of the military's interference in civilian rule and a defender of the rule of law.
The tempo of the game slowed massively following Aguero's second goal, but Manchester City still retained possession on the edge of the Leicester box, using their surgeon-like approach to wear the visitors out. Subs: Simpson 5, Mahrez 5, Iheanacho 5. It was a classic City goal, and gave them an immediate advantage to build on as Leicester began to seek an equaliser, allowing space for the home side to break into. Sterling gets the hosts off to a flyer! De Bruyne curled in a unsafe low ball behind the defense and Sterling turned it home.
24' - GOAL! Man City 1-1 Leicester City. The best bet is the over 2.5 goals is since Manchester City will probably get 3 goals on their own.
DF Aymeric Laporte, 7 - As with his centre-back partner, he was in some way culpable for the Leicester goal as he should have closed Vardy down quicker. He also notched in the seventh straight home match for the first time.
Chelsea face Barcelona in the first leg of their Champions League last-16 tie on 20 February before visiting both Manchester United and Manchester City in the league and then making the return trip to the Camp Nou on 14 March.