And while they were not at their best, Klopp was left to reflect on a Liverpool performance that improved throughout.
Right-back Joe Gomez is unlikely to feature because of a minor knee problem while midfielder Adam Lallana returns after a thigh problem.
With draws against Watford, Spurs and Brighton and a win over West Brom in the league as well as two FA Cup wins by a 1-0 scoreline against Fulham and Watford, Saints will have confidence going into this game.
In terms of form, Liverpool have had a mixed start to the new year with league wins away at Burnley and Huddersfield as well as becoming the first side to beat runaway league leaders Manchester City domestically this season.
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"It won't be a friendly game, they fight for everything, we fight for everything".
"We did what we wanted to do and knew the strength of Southampton".
The Reds have had a odd start to 2018, becoming the first team to beat Man City in the Premier League this season before losing to Swansea and West from in successive matches. Mohamed Salah doubled Liverpool's score in the 42nd minute.
"I think our fans are really respectful with ex-players and I prefer that our fans are focused on supporting our players and get behind us".
Liverpool boss Jurgen Klopp on Southampton explained: "They're a good team, to be honest I don't get why they are in the region of the table they are".