Federer, who earned his fifth title at Indian Wells past year, saved a set point in the second-set tiebreaker and advanced to face Filip Krajinovic on Monday. "Very weird", Djokovic said. I just completely lost rhythm, everything.
Djokovic scrambled to win the second set on Sunday but the rust from the layoff was evident as he made 62 unforced errors overall.
"It feels insane. I mean, I'm still in shock", Anisimova said.
Frenchman Gael Monfils survived a match point before beating big-serving American 15th seed John Isner 6-7 (5-7) 7-6 (7-3) 7-5.
On Sunday, he finished off his two-day 6-3, 7-6 (8-6) victory over Federico Delbonis to set up a third-round clash with 25th seed Filip Krajinovic yesterday (this morning, Singapore time).
Sela also took the second set by the same score to seal a 6-4 6-4 victory in 91 minutes against world number 24 Edmund, who replaced the injured Andy Murray as British number one earlier this month.
"When you go from night to day [you are usually] playing a different opponent - so, naturally, it's all a change", said Federer.
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Federer is making his 17th appearance in the California desert and is assured of remaining world number one if he makes it to the semi-finals.
Federer said he understands well how even a champion like Djokovic could be struggling to find his game so soon after having surgery.
Djokovic said it felt like the "first match I ever played on the tour".
Federico was off to a better start in set number two, holding easily in the opening two service games to be leveled at 2-2 before the rain started to fall, forcing the organizers to call it a day and move the match into Sunday's program.
"But it's not easy to deal with this kind of frustrations after injuries or when you always be the favorite to win a tournament, you come here and you lose in first round".
"He just seems to be getting better and better, he's improving year on year and as we said earlier, he's won nine titles since coming back from that injury problem with the knee".