Their brilliance in City's outstanding Premier League campaign to date has been recognised by their peers, with Tottenham striker Harry Kane, Liverpool forward Mohamed Salah and Manchester United goalkeeper David De Gea making up the six-man shortlist for the award.
The winners will be announced on Monday 23 April at the PFA Awards.
City's Belgian star has been largely superb all season and was at his best early in the term as the Sky Blues took a stranglehold on the Premier League title.
Given City's vast campaign, it is no surprise to see De Bruyne joined by Sane and Silva.
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De Bruyne tops the assist leaders with 15 and has also contributed seven goals, Silva has 11 assists and eight goals while Sane has 12 assists and nine goals.
Since the Premier League was reduced to 20 teams for the 1995-96 campaign, only six players have hit the 30-goal barrier-Alan Shearer, Kevin Phillips, Thierry Henry, Cristiano Ronaldo, Robin van Persie and Luis Suarez-while no player has ever passed 31 goals.
Since his summer move to the Merseyside outfit, the 25-year-old has been in sensational form for Jurgen Klopp's side with 39 goals across all competitions, including 29 efforts to top the Premier League goalscorers' chart.
Manchester United goalkeeper David de Gea completes the shortlist. His reward is a place on the Young Player of the Year shortlist.
Among his rivals for that prize is 17-year-old Fulham left-back Ryan Sessegnon.