The runaway leaders have seen their Champions League hopes torn to shreds by Liverpool and were denied, if only temporarily, their title celebrations by derby rivals Manchester United last Saturday evening. Guardiola may even rest Leroy Sane, who has played 90 minutes in City's last four games, and is probably in need of a rest.
Lloris beat away a rasping David Silva drive in the 33rd minute but City's level dropped markedly before half-time to allow Spurs back into the contest.
While City's morale is down and the Premier League title all but won, Spurs have something to play in this clash.
Today, we've done it many, many times and that's why we're in the position we are.
Tottenham, who had gone 14 matches unbeaten in the league since losing 4-1 at City in December, are seven points above fifth-placed Chelsea in the race for Champions League qualification.
Beyond the inevitable title win though, it has been a season of records broken by the Shark Team, and more may still follow before the campaign ends. We have already shown that we are ready to compete.
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The 25-year-old has had to be happy with a place on the fringes of the Arsenal first team since joining from Basel in January 2016.
After sweeping through most of the season in regal fashion, City had crashed down to earth with a bump over the last 10 days. "We need to do our thing and hopefully we can finish it off next week".
However, they now enjoy a six-point cushion over Southampton thanks to a thrilling 3-2 win over Brighton at Selhurst Park with Wilfried Zaha scoring twice.
Harry Kane added to his goal tally this season with the slightest of touches to direct Christian Eriksen's free-kick home for a 2-1 win against Stoke.
A host of Premier League clubs are set to battle it out this summer to sign Paris Saint-Germain star Layvin Kurzawa after the defender admitted he wants to leave the club.
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"When you play against the other teams in the top six, as opposed to the teams in the bottom half, the game is very different". Tottenham are perhaps the only side in the Premier League capable of pressing and counter-attacking against City in a similar manner to Liverpool, and this could be a genuinely tricky game for Guardiola's side.