New study says women with early stage breast cancer can avoid chemotherapy

The study is thought to be the largest breast cancer treatment trial ever

Image The study is thought to be the largest breast cancer treatment trial ever

A POTENTIAL cure for cancer may have been found in the U.S. after a woman suffering from an "incurable" breast cancer that had spread to some of her organs was cured of the killer illness.

The study gave 10,273 patients a test called Oncotype DX, which uses a biopsy sample to measure the activity of genes involved in cell growth and response to hormone therapy, to estimate the risk that a cancer will recur.

Bottom line: Figueredo said the study found approximately 70 percent of women with that type of cancer do not need chemo therapy.

Roswell Park Comprehensive Cancer Center researchers have identified significant differences in the immune microenvironment of breast cancer tumors between African-American and white women, shedding light on the ways in which race can influence cancer development and outcomes. "I spoke to four people about her case, including one of the doctors associated with the Tailorx trial", said Dr Ramesh Sarin, senior consultant surgical oncology at the Indraprastha Apollo Hospitals. Half of that group also got chemotherapy.

While previous studies demonstrated that patients with low scores (10 or lower) did not need chemotherapy, and women with high scores (above 25) did require and benefit from chemotherapy, there was no conclusive research guiding patients and doctors on whether or not to undergo chemotherapy in cases with a tumor with a midrange score, according to the study. "It's a technique done in a laboratory", she said.

Physicians are hailing the study as a major breakthrough that will help women avoid the devastating side-effects of chemo which include hair loss, infertility, pain, and possibly death.

Cancer doctors said the findings would change practice in United Kingdom clinics, and meant women in this group could be treated safely with just surgery and hormone therapy.

"Patients really struggle having to make that decision, and now they don't have to".

The findings only apply to women with specific early stage breast cancers.

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"If confirmed in a larger study, it promises to further extend the reach of this T-cell therapy to a broader spectrum of cancers".

Oncotype Dx is a test created to predict the risk of breast cancer coming back.

"I anxious that there were cancer cells left over in my body that were spreading everywhere because I didn't have the systemic treatment", Mall recalled. The National Cancer Institute provided $36 million, and $4.5 million of it came from the money collected from the stamp.

"Metastatic breast cancer remains incurable, and if we are to finally stop women dying we urgently need to find new ways to target and stop the spread of the disease".

"At lot of works needs to be done, but the potential exists for a paradigm shift in cancer therapy - a unique drug for every cancer patient - it is very different to any other kind of treatment".

This resulted in a "highly personalised" anti-cancer therapy that yielded "complete tumour regression", the researchers wrote. Key secondary end points included freedom from recurrence of breast cancer at a distant site, freedom from recurrence of breast cancer at a distant or local-regional site, and overall survival (OS).

It provides important information on a safe way to cut back treatment, an issue that has prompted vigorous debate not only for breast cancer but also for other malignancies.

About 40,920 women in the US are expected to die in 2018 from breast cancer, though death rates have been decreasing since 1989.

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