Bourdain was found dead in his hotel room in France.
"It is with extraordinary sadness we can confirm the death of our friend and colleague, Anthony Bourdain", CNN confirmed in a statement.
CNN said its thoughts are with his daughter and the rest of Bourdain's family at this incredibly hard time. He used Parts Unknown to show Americans the weird and wild parts of their own country with episodes on Koreatown in Los Angeles, New Mexico, Detroit, the Mississippi Delta, Montana and West Virginia.
As he left the White House for the G-7 summit in Quebec, President Donald Trump, whom Bourdain had sharply criticized, offered his "heartfelt condolences" to Bourdain's family, which includes his 11-year-old daughter, Ariane.
"Anthony gave all of himself in everything that he did", Argento wrote. I was crushed this morning to wake up and find out that it won't ever happen because Anthony Bourdain, the patron saint of square pegs exhausted of being expected to fit into round holes, took his own life.
Bourdain was filming an episode of CNN's award-winning show Parts Unknown when this tragic incident happened.
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A gifted storyteller, Bourdain promoted haute cuisine and street food alike in his travels, encouraging viewers to "eat and drink with people without fear and prejudice". "One of the great storytellers of our time who connected with so many".
Bourdain, born in New York City, had been open in the past about his history with substance abuse.
'He was my love, my rock, my protector.
"He was a great man and I cherished the opportunity meeting him", Najmi said. "I would ask that you respect their privacy and mine".
Bourdain's girlfriend, actress Asia Argento, also issued a short statement on Twitter.
Bourdain seems to have been the latest in the cases of high-profile suicides as a result of mental illness.
Almost 45,000 people committed suicide in 2016, making it one of three leading causes of death that are on the rise, along with Alzheimer's disease and drug overdoses.