After wasting a handful of first-half chances while living dangerously in their own half, Hirving Lozano's 35th-minute strike on the break proved just reward.
Mexico's fans celebrate victory of their team after the match. It was a major milestone for the team.
But Osorio's team has been criticized for some of their performances since qualifying, including a 2-0 loss to Denmark in their final warm-up game, as well as a players' party at the end of their World Cup preparations.
One social media user commented: "Fans causing artificial earthquakes in Mexico City".
In Mexico City, the celebrations were so wild when Hirving Lozano scored in the first half, they registered on seismographs, effectively causing a small quake.
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"We want to get the three points".
"I put it down to stress, first match nerves, that's true for me too", the Brazil boss said.
"In the first half we played very badly, we were not able to impose our usual way of playing, attacking and our passing were not effective in the spaces, there were lots of counter-attacks and we had to get back".
Aside from Brazil who successfully defended the World Cup in 1962 after winning in 1958, no other country has been able to defend their World Cup crown. It is the only way we know how to play. Germany then dominated but when it broke through the Mexican defense, the shooting was poor.
The 26-year-old was fouled 10 times in the match, the most for any player in a World Cup match since Alan Shearer in 1998. He has tinkered with his lineups constantly. That set the tone for Mexico to torment Germany on the counterattack, with Lozano taking full advantage of right back Joshua Kimmich's tendency to go forward. "In many previous tournaments we've always won the first match but we have to accept it", Loew said.
"It's pretty simple: we played like we did against Saudi Arabia, but this time it was against a better opponent", fumed the Bayern Munich player, who was booked for a foul in the dying stages.