Syrian state media said on Monday that US -led coalition aircraft had bombed "one of our military positions" in eastern Syria, leading to deaths and injuries, but the USA military denied carrying out strikes in the area.
Syrian state media reported the attack overnight and accused the US -led coalition against Daesh terror group, saying a number of people were killed.
USA forces also are based around the Tanf crossing, southwest of the town in the Syrian desert near the borders of Iraq and Jordan.
"Clashes renewed between SDF fighters, backed by International Coalition warplanes against the last remaining ISIS pocket in the east bank of Euphrates River", the SDF said.
A commander in the military alliance backing the Syrian President, Bashar al-Assad said drones, "probably American", had bombed positions of Iraqi factions between Albu Kamal and Tanf and Syrian military positions.
"No member of the U.S. -led coalition carried out strikes near Albu Kamal", said Major Josh Jacques, a U.S. Central Command spokesman, to Reuters. The Iraqi officials spoke on condition of anonymity because they were not authorized to speak to the media.
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Pro-government forces, supported by Russian Federation and Iran, and a US-backed alliance of Kurdish and Arab fighters are both battling Islamic State (IS) militants there. The official said the Pentagon was going out of its way to publicly make clear that it was not involved in the strike in order to minimize the risk of retaliation. The Syrian Observatory for Human Rights reports that 40 pro-Assad regime fighters were killed in the strike.
Asked about the reported air strikes, an Israeli military spokeswoman said: "We do not comment on foreign reports".
According to CNN, Sunday's strike is unlike those normally carried out by Israel, as those attributed to Israel tend to occur in Syria's western region, around Damascus and Homs, and mostly targeting Iran's infrastructure and military presence in Syria.
Syrian and Iraqi forces have driven ISIS from virtually all the territory it once held in both countries, but the terrorists still control some remote areas along the border.
An Iraqi paramilitary force Monday accused the United States of killing 22 of its fighters in an overnight air raid just inside Syria's border with Iraq that a monitor said left dozens dead.