El Tri sliced the German defense over and over with counterattacks, and Hirving Lozano cracked it open, cutting back to spin around Mesut Ozil and beat goalkeeper Manuel Neuer from about 10 yards in the 35th minute.
Germany will now look ahead to their next group match against Sweden and Low hasn't shied away from the fact that it is imperative that his side get a result.
There have also been two defeats to Argentina, one to Bulgaria on penalties, one against Germany - where they also led until well into the second half - and an especially painful one against neighbours the United States. With the trio of Hirving "Chucky" Lozano, Carlos Vela and Miguel Layun playing behind striker Javier Hernandez, it became obvious that the Mexicans meant to take the game to its more illustrious opponents. Its great to start on the right foot, against the reigning world champions.
"I don't know if it's the biggest victory in (Mexico's) history, but one of the biggest for sure", Lozano said after the game.
On the way to that latter title, Germany saw off Mexico, who have themselves grown under the tutelage of Juan Carlos Osorio, in charge since 2015.
"It's disappointing to have lost the first match". Should Mexico be able to hold on and win the group, and assuming Brazil recovers from its surprising stumble of a draw against Switzerland, Mexico could escape to the knockout round with a much more favorable matchup, and potentially finally break through to the quarterfinals for the first time since 1986.
European dominance continues at 2018 World Cup
South Korea game was one of the poorest of the tournament so far, with the Asian nation failing to muster a single shot on target. It's remarkable that of the 13 European teams to have played so far in Russian Federation 2018, only one (Germany!) has lost.
He said: "They were very good, they played a very clever game".
Thousands of supporters took to the streets on Sunday to cheer their national team's long-shot win against the World Cup holders in Mexico's first match of the 2018 tournament.
And when Hirving "Chucky" Lozano shattered the first-half deadlock - the only breakthrough needed during a 1-0 stunner - you probably would have felt the splash of Azteca's beer-spraying tradition, a sheet of suds splashing below.
All eyes will be on West Ham striker Javier Hernandez who has a trio of World Cup goals to his name in two tournaments.
However, when they faced off with Mexico, things didn't go as planned for them.
"For the players today, the phrase was to play for the love of winning and not the fear of losing. and that is what exactly what they did". Germany, meanwhile, has to regroup.
Sunday's remarkable win over the world champions, however, has suggested that this Mexico team are psychologically stronger than their predecessors and that may just help them take the extra step.