Suarez, who on Wednesday will make his 100th appearance for the national team, missed a glut of chances in the 1-0 win over Egypt in their opening Group A game, when Jose Gimenez's late header saved his blushes.
Saudi Arabia will play Egypt that same day in Volgograd.
After sneaking past Egypt in their World Cup opener with a stoppage-time victor, Uruguay will field a veteran side containing seven players aged 31 or over against Saudi Arabia as they seek a victory that would seal their place in the last 16.
Luis Suarez marked his 100th worldwide cap by sending Uruguay into the last 16 of the World Cup as the striker benefited from some poor goalkeeping to eliminate Saudi Arabia with a 1-0 win.
The Sky Blue should have beaten Egypt by a wider margin than they did but Luis Suarez could not finish multiple chances.
In truth, it was another stuttering display from Oscar Tabarez's Uruguay team.
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But Group A favourite Uruguay is still widely expected to clobber Saudi Arabia, the second-lowest World Cup team in the Federation Internationale de Football Association rankings at No. 67.
The Saudis continued to move the ball around but barely threatened the typically gritty Uruguay defence.
Saudi Arabia was drawn into Group A and lost its World Cup opener 5-0 to host nation Russian Federation.
The three points and a last-16 spot should have been wrapped up just after the hour mark, but Sanchez headed over when unmarked at the back post from a wonderful Edinson Cavani cross.
Uruguay showed all their know-how and experience, though, as Atletico Madrid defensive pair Jose Gimenez and Diego Godin helped see out the closing moments easily.
Paris Saint-Germain striker Cavani came close to emulating Suarez by scoring in a third World Cup, but his low shot was smothered by the onrushing Al-Owais.