In a match, which started after 20h00 on Friday night with the Centre Court roof already shut, that had to be carried over to be completed on Saturday with Djokovic leading by two sets to one.
Novak Djokovic advanced to Sunday's Wimbledon final, defeating world No. 1 Rafael Nadal on Saturday in what remained of their Centre Court semifinal that was suspended Friday by the tournament's 11 p.m. curfew.
- Anderson is bidding to become the first South African man to win the Wimbledon title and just the second to win a Grand Slam title after Johan Kriek, who won the title at the 1981 Australian Open.
He also said his semi-final should have been played before the Anderson-Isner match on Friday.
Ultimately, the cheeky fan who had called for Nadal to be on court would get his wish, as the Spaniard took the court against Djokovic at around 8pm local time.
Djokovic, the Wimbledon champion in 2011, 2014 and 2015, will be bidding for a 13th Grand Slam title when he faces Anderson on Sunday.
"Right now I feel awful", the 33-year-old Isner said, noting he developed a foot blister at some point in the match.
"He's coming off from two epic marathon five-set wins".
The Serb, a three-time Wimbledon champion, is ahead 6-4 3-6 7-6 (11-9).
Known for his marathon matches, the ninth-seeded Isner lost to the eight-seeded Anderson in a grueling six-hour-and-36-minute match, with the final set alone lasting for almost three hours. "I really hope we can look at this, because at the end you don't feel great", Anderson said.
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The match is being played with the Centre Court roof closed - the same conditions that the first three sets were played under. Kerber, a left-hander, is ranked 92 worldwide and has won two major titles: the 2016 Australian Open and the 2016 U.S.
The Florida-based Johannesburg-born player has spent 21 hours on court getting to the final.
Djokovic hasnt won a major in more than two years, dealing with an injured right elbow that was so painful in 2017 he quit his quarterfinal at Wimbledon and sat out the rest of the season.
Isner was bidding to become the first US man to make a Grand Slam singles final since Andy Roddick at 2009 Wimbledon, to end the nation's longest drought in his 41st career Grand Slam.
As John Isner endured the second-longest Grand Slam match in history - and his second-longest match in Grand Slam history - he asked chair umpire Marija Cicak to end the madness with a tiebreak.
That point ended up actually setting up the winning break for Anderson. I don't really know what to say right now.
Isner is still seeking his first Grand Slam final appearance.
On Saturday, Nadal and Djokovic returned to finish the job.
Although Djokovic held more convincingly for most of the first set and some of the second, Nadal in the third reverted to the drop shot that had proved so effective towards the end of his five-set win over Juan Martin del Potro in the quarter-finals on Wednesday, and he began to trouble his old rival in the 52nd meeting of their rivalry.
"A couple times I lost my cool, then I lost my serve, then a set".
"It's long overdue", Isner said.