Madrid's loss should be Barcelona's gain, making the team the clear favourites to retain their La Liga title even after midfield great Andres Iniesta left for Japan and Paulinho returned to the Chinese league.
"I know who's playing in goal tomorrow, but I'm not telling you", said Lopetegui, who also has three-time Champions League victor Keylor Navas in his squad. I am sure that we will see a talented Real Madrid with a good mentality, as that's what we all want.
Diego Costa gave Europa League holders Atletico a dream start against Champions League winners Real by firing them ahead after 49 seconds, knocking down a long pass and smashing the ball into the net from a tight angle.
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Ronaldo left for Juventus this summer after nine spectacular years at the club, who appeared to miss his driving influence heavily in their first match without him - and their first match under new boss Julen Lopetegui.
"If we'd won 2-1, we'd be talking about things in a different way". Midfielders Francisco "Isco" Alarcon and 22-year-old Marco Asensio should also play more consistently.
"We have to get the most out of the team and start to lift ourselves up now and start thinking about a league season which we are very excited about". "Congratulations to Atletico, they deserved to win".
Julen Lopetegui's Madrid open their LaLiga campaign against Getafe at the Santiago Bernabeu on Sunday.
He takes over from Zidane, who stepped down after becoming the first manager to win three successive Champions League titles.