The Frenchman, who now has a thigh injury, was sentenced this week for the August offence, with a judge fining him £50,000 and banning him from driving for 20 months.
Just as importantly for the home team, key midfielder Dele Alli is also expected to miss the match against the Reds, after picking up a hamstring injury with England.
Pochettino said: "He already knew in the moment that it was a big mistake".
"Today, if you make a lot of mistakes, then of course in front is Liverpool, one of the best teams in Europe". He is punishing himself.
Pochettino said Lloris would remain captain despite his drink-driving case, replying "of course" when asked whether that would be the case.
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'That's why expectations and perspective are completely different to other players.
Pochettino added: "I am not a person who suffers too much". I do not read and do not listen to what is going on around. It's under control. I think he's fit.
Mauricio Pochettino has said there are no concerns from him regarding the long-term fitness of Harry Kane, despite some in the media questioning whether he is suffering from fatigue. "We take the decision and we try to take the best decision for the player and of course the team".
Even after signing a new deal, Napoli are still desperate to hold onto their midfielder but a mouth-watering offer that can not be resisted has to be made for the 24-year-old.
When sentencing, the magistrate said the fine represented the seriousness of the offence as well as the goalkeeper's financial means.
"We are disappointed because we are going to miss him for this game and maybe against Inter in the Champions League. It's not a situation that worries us".