It forms part of a packed line-up of great fights coming up soon, with Saul "Canelo" Alvarez fighting "GGG" Gennady Golovkin, Anthony Joshua vs Alexander Povetkin and even Floyd "Money" Mayweather set to face Manny Pacquiao once more.
Joshua, the 2012 Olympic champion in London, comes into Saturday's contest - with 80,000 spectators expected - having won all 21 of his professional bouts, although his last fight, against New Zealand's Joseph Parker in Cardiff in March, saw him go the distance for the first time as a pro before he secured a unanimous points decision.
Today will also mark Joshua's debut on the new DAZN streaming service.
World Boxing Association (WBA) and World Boxing Organisation (WBO) titles will be on the line - weighed in yesterday at 17 stone 8 pounds (111.5 kilogrammes), whilst 39-year-old Povetkin tipped the scales at 15st 12lbs.
"Skills and technique apart, we both have a big heart and can dig deep", said Joshua.
Saturday is the first of a two-fight deal at Wembley and Joshua said he felt at ease. "We both showed that against Klitschko". The one loss came at the hands of Klitschko back in 2013.
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David Luiz and Antonio Rudiger have been Sarri's preferred partnership, with Andreas Christensen coming in on Thursday when Luiz was rested.
"That's what I say in boxing, there's no league one, league two.You are either the best or you're not".
"Not only this fight with Povetkin - every fight I've been in and every future fight I'll be in".
Where: Exclusively on DAZN, which is available at $9.99 per month following a one-month free trial - making tonight's fight a free viewing for all. Anthony is a very strong fighter but I am just as strong. He gets caught with that more than any other punch and Joshua throws that well. "I have Anthony Joshua in my sights and that's all I'm focused about is this fight".
"I'm a physical, strong guy, who knows how to box".
Povetkin, the mandatory WBA challenger and like Joshua a past Olympic gold medalist, had weighed in for his previous fight against Britain's David Price at 16 stones five pounds.