According to an AP report, the first lady was "joyously welcomed at the airport" by a troupe of women singing and dancing, but "a few signs of protest were afoot, too, as President Trump is not widely seen as a friend of Africa".
Kenyan first lady Margaret Kenyatta accompanied Trump on the safari, and the pair is expected to take in a traditional performance later Friday.
"Thank you for what you do and taking care of them", Mrs. Trump said, while holding a baby girl originally handed to her wrapped in a blanket bearing the logo of Be Best, the child welfare initiative she launched this year and is promoting during this week's Africa visit.
Many past American first ladies have also made trips to the African continent, including Michelle Obama, Laura Bush and Hillary Clinton. "Takulandirani [Welcome] First Lady Melania Trump" was spelled out in red, white, and blue letters on the chalkboard.
The national park is where 105 tonnes of ivory have been burned to discourage the trade.
Trump is trusted less than Putin and Xi, global study finds
German Chancellor Angela Merkel was the only leader in whom the majority of those surveyed - 52 per cent - expressed confidence. Despite the unease many feel about the U.S.at the moment, the idea of a USA -led global order remains attractive to most.
Despite the president's previous statement, Afful said that "she has come to see how wonderful we are".
US President Donald Trump has tweeted that his wife Melania Trump "is doing really well in Africa".
Ms Trump then took to the Nairobi National Park and will later visit an orphanage and watch a play.
But if the comments appear to have bothered the First Lady she didn't it show it as she toured outdoor classrooms at Chipala Primary School in Lilongwe, which receives assistance from the US Agency for International Development.
As she led the team, the other children sang as they marched and danced towards a shelter surrounded by journalists with camera's and security agents. "It is a lovely thing to see", Mr Trump tweeted on Thursday, 4 October.
She will finally wrap-up her four-nation tour in Egypt and Malawi.