The confirmation will mark a major victory for President Donald Trump, who will soon be able to take credit for appointing two conservative justices to the Supreme Court during his relatively brief time in office so far and possibly create a conservative majority on the bench for a generation.
Trump watched the vote on a large-screen television tuned to Fox News in a wood-paneled cabin on the plane.
Protesters gather on the steps of the U.S. Supreme Court building after over running police barricades while demonstrating the confirmation of Associate Justice Brett Kavanaugh Saturday in Washington, D.C.
Every Democrat voted against the Trump appointee, except for Sen.
With tensions simmering, Pence got an earful from activists who booed and chanted "Vote them out!" as he walked to his motorcade. Support from Collins and Manchin would give Kavanaugh at least 51 votes.
"I've done so much for Alaska, I'm shocked to see her vote", he said.
At the request of Democrats and a Republican senator the Federal Bureau of Investigation was called in to look into the allegations - but was unable to corroborate their stories.
Anticipating Kavanaugh's confirmation, some groups have explored the impeachment process for removing him from the high court. "I might have been too emotional at times", Kavanaugh wrote. Republicans emerged confident that the FBI investigation into the allegations unearthed no new corroborating details.
"The Democrats are willing to cause such destruction in the pursuit of power, just imagine the devastation they would cause if they ever obtained the power they so desperately want and crave", Trump said.
Protesters gather at Capitol ahead of Senate vote on Kavanaugh
But Collins addressed the 2020 election in an interview with News Center Maine (WCSH/WLBZ) shortly after Saturday's vote. That is a state that President Donald Trump won by a very large margin - by more than 40 percentage point, in fact.
Former President George H.W. Bush tweeted support for Collins from Kennebunkport, praising her before the final vote for "political courage and class".
"I do not believe that these charges can fairly prevent Judge Kavanaugh from serving on the court", the senator said on the Senate floor.
Trump, throughout the day, insisted Kavanagh would not be tainted by the sexual assault allegations from Christine Blasey Ford and others that almost tanked his nomination. "But then I found out he was a fraud - he never went to Vietnam", he said.
Despite weeks of pointed and tempestuous questioning by senators, Brett Kavanaugh, a 53-year-old Yale graduate, who rose to prominence as a member of Ken Starr's legal team, which led the campaign to impeach Bill Clinton two decades ago, appeared set for a relatively straightforward confirmation.
Mr Trump also said he was "100% certain" that the woman who had accused Mr Kavanaugh of sexual assault, Christine Blasey Ford, had named the wrong person. That rare procedural maneuver left Kavanaugh with the same two-vote margin he'd have had if Murkowski and Daines had both voted. She and Kavanaugh testified at a raucous September 27 hearing, where he angrily and tearfully denied her allegations.
"It's really just been a continuation and sometimes an escalation of what we saw in 1987", Leonard Leo, a White House adviser on Supreme Court nominations, said after leaving the Senate's public gallery following the vote on Saturday.
Mr Kavanagh was sworn in nearly immediately by Chief Justice John Roberts, according to a statement from the court.
Leo, who will return later this month to his role overseeing the Federalist Society, said he thinks that every one of the nine seats is "equally important" but that he realized the Powell-Kennedy-Kavanaugh slot is a "historic seat" for its pivot point on the ideological tilt of the court.
He spoke of "intimidation by the mob" and said the Senate vote should be one "to turn away from darkness". "I have to do what I think is right, and that's what I did", she told WCSH-TV.