Sadio Mane has broken a bone in his left hand while away with Senegal for African Cup of Nations qualifiers and won't play against Sudan on Tuesday.
While there is yet to be official word on the extent of injuries to Mohamed Salah and Virgil van Dijk, with Sadio Mane's name now being added to Liverpool's injury list, Jurgen Klopp will be even more frustrated with the worldwide break than usual.
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Now, however, with three key Liverpool starters injured and no word on how serious each injury is, it's not looking good for Klopp and he will be understandably frustrated with how things have panned out.
Van Dijk has been an ever-present at the back for Liverpool so far this season, starting all eight of their Premier League matches, and will hope to shake off the injury in time to face Huddersfield on Saturday.
The centre-half returned to England early following an agreement between Liverpool's medical staff and his national team.
Van Dijk too is in line to play the match at the weekend, struggling with a rib injury on worldwide duty.