The auction that will be live between October 31 to November 8, also features a signed photocopy of Hawking's PhD thesis.
Christie's, a global auctioneer headquartered in London, is selling several of Hawking's papers, including his dissertation, thesis on the origins of the universe and his spectrum of wormholes.
Perhaps the most sought-after artifact in the auction will be one of five existing copies of Hawking's 1965 Cambridge University Ph.D. thesis, " Properties of Expanding Universes", which carries an estimated price of £100,000 to £150,000 ($130,000 to $195,000).
Medals, awards, scientific papers and the script for one of Prof Hawking's appearances on The Simpsons will also be going under the hammer as part of the sale, entitled On the Shoulders of Giants.
Aside from some of Hawking's possessions being offered, possessions from other famous scientists, including Sir Isaac Newton, Charles Darwin and Albert Einstein will be included in the auction.
Handwritten on the front is a confirmation from Hawking that it was his original work.
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Additionally, a few more whimsical items will be up for sale, including a copy of the script for a Simpsons episode he was featured in.
The motorized wheelchair that carried Hawking out of the 1980s and into his most high-profile period also is on the auction block, with Christie's reportedly expecting it to fetch between $13,000 and $20,000. Meanwhile, Hawking's wheelchairs have become a symbol for his disability.
"The lots selected for sale highlight Professor Hawking's remarkable achievements in science alongside his unique personality and inspirational life story", Thomas Venning, Head of the Books and Manuscripts department, said in a statement.
The scientist was diagnosed with motor neuron disease at the age of 22 and was eventually strapped into his wheelchair, unable to walk again. The copy comes with a bomber jacket that Hawking once wore.
Daughter Lucy Hawking has noted that, through the auction, fans of the scientist will get the chance to become owners of the relics, reminding about the odd life of a theoretical physicist. The money made during the auction will go toward the Motor Neurone Disease Association and the Stephen Hawking Foundation, which supports research related to both physics and the disease.
In addition to publishing numerous scientific papers, Hawking wrote books, and his popular "A Brief History of Time" will be at the auction.